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1994-08-09
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Document 0155
DOCN M9480155
TI Comparison of four commercial enzyme-linked immunosorbent and one
agglutination assays for the detection of HIV antibodies in sera from
Zimbabwe.
DT 9410
AU Tswana SA; Moyo SR; Nystrom L; Blomerg J; Department of Medical
Microbiology, University of Zimbabwe; Medical School, Harare.
SO Cent Afr J Med. 1993 Oct;39(10):198-201. Unique Identifier : AIDSLINE
MED/94291172
AB Sera from 871 AIDS and AIDS related complex patients were used to
evaluate four ELISA and one agglutination assays. Commercial tests
compared were Abbot, Wellcoyzyme, Biotest, Du Pont and Serodia.
Wellcozyme and Serodia had the highest sensitivity (96.8 pc and 98.8 pc
respectively) but the lowest specificity (53.3 pc and 46.5 pc
respectively). Du Pont was the least sensitive test (89.1pc). Biotest
and Abbot were comparable--Biotest had a higher sensitivity (93.2pc as
compared with 90.6pc) but Abbot had a higher specificity (94.1 pc as
compared with 89.1 pc). Thus, Abbott and Biotest both had a satisfactory
high sensitivity and specificity and could thereby be recommended for
use in screening of HIV-1 antibodies in south east Africa.
DE Acquired Immunodeficiency Syndrome/*BLOOD/EPIDEMIOLOGY/PREVENTION &
CONTROL Agglutination Tests/*STANDARDS AIDS-Related
Complex/*BLOOD/EPIDEMIOLOGY/PREVENTION & CONTROL Blotting, Western
Comparative Study Enzyme-Linked Immunosorbent Assay/*METHODS/*STANDARDS
Evaluation Studies Human HIV Antibodies/*BLOOD *HIV-1 *HIV-2 Mass
Screening/METHODS Sensitivity and Specificity Support, Non-U.S. Gov't
Zimbabwe/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).